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In comparison with the dad or mum molecule, tenofovir, tenofovir alafenamide presents a lipophilic group that masks the damaging cost from the father or mother moiety which enhances its oral bioavailability.
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Tenofovir alafenamide provides ninety one% lessen plasma concentration using an intracellular existence of about twenty-fold higher when put next to tenofovir disoproxil. This is because of its extended systemic publicity and its bigger intracellular accumulation from the Energetic metabolite tenofovir diphosphate.
Không sử dụng HepBest – tenofovir alafenamide 25mg ở bệnh nhân suy thận giai đoạn cuối (thanh thải creatine thấp hơn 15 mL/phút)
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